ABSTRACT: The presence of antisperm antibodies (ASAs) in infertile males is the underlying cause of 'immune infertility'. The 
mechanism by which ASAs induce male infertility is not completely comprehended. Immune infertility is caused by the presence 
of antisperm antibodies (ASAs). While this form of infertility is very uncommon in men, it is crucial from a clinical and theoretical 
standpoint to comprehend the implications, targets, risk factors, and causes of male reproductive issues induced by ASAs. The main 
factors contributing to the cause of this condition are well recognized as anomalies in the blood-testis barrier and/or blood
epididymal barrier. Among the various parameters impacted, sperm motility is the most commonly detected. The present study 
elucidates the fundamental principles of ASAs, as well as their causes and risk factors.